期刊
MICROPOROUS AND MESOPOROUS MATERIALS
卷 172, 期 -, 页码 118-124出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micromeso.2013.01.028
关键词
Mesoporous silica; Drug delivery; Doxorubicin; pH-sensitive; Surface modification
类别
资金
- NRF [2010-0017552]
- Ministry of Health & Welfare, Republic of Korea [A062254]
- Ministry of Education, Science and Technology
We prepared selectively functionalized, spherical mesoporous silica particles (SMSPs) with a polyethylene glycol (PEG)-grafted outer surface and a doxorubicin-grafted inner surface for drug delivery. The SMSPs were fabricated by co-condensation of an amphiphilic organotriethoxysilane with a thermally cleavable urethane bond and tetraethoxysilane (TEOS) in the presence of cetyltrimethylammonium bromide (CTAB) under basic conditions. The outer surface of the as-precipitated silica particles was functionalized by grafting with 3-(triethoxysilyl)propyloxy-PEG. The PEG-grafted SMSPs were refluxed in methanol in the presence of HCl, resulting in the removal of surfactant molecules and the formation of a methoxy urethane group tethered to the pore wall. After the reaction of the methoxy urethane group with hydrazine, doxorubicin was chemically introduced into the pores through a pH-sensitive hydrazone linkage. A high loading content was achieved through chemical loading followed by physical loading. The doxorubicin-loaded SMSPs showed a pH-sensitive and sustained release behavior. (C) 2013 Elsevier Inc. All rights reserved.
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