Mesoporous bioactive glasses for controlled drug release

Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition. (C) 2007 Elsevier Inc. All rights reserved.