期刊
MICRON
卷 41, 期 3, 页码 268-272出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micron.2009.11.003
关键词
Elastin; Tropoelastin; Hydrogel; Macro-assembly
类别
资金
- Australian Research Council
- National Heart Foundation
Synthetic human tropoelastin was chemically cross-linked to form elastic hydrogel-like structures in vitro. Discrete stages were identified during elastic hydrogel formation by cross-linking tropoelastin with bis(sulfosuccinimidyl) suberate at a range of protein concentrations during this process. In the early stages of this process, particles with the same dimensions as tropoelastin were seen. As hydrogel formation progressed, monomer width fibres were also observed. Overall, four distinct stages were identified: (1) tropoelastin monomers form discrete particles in the order of 200 nm diameter, (2) these particles merge to form larger spheres, (3) spheres coalesce into open linked networks, (4) coalesced spheres consolidate to form a porous structure to give synthetic elastin hydrogels. (C) 2009 Elsevier Ltd. All rights reserved.
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