期刊
MICROFLUIDICS AND NANOFLUIDICS
卷 15, 期 2, 页码 173-181出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-013-1140-x
关键词
Paper-based; Microfluidics; Lamination; Capillary flow; Glucose
资金
- National Science Foundation [OISE-0968313]
- Office Of Internatl Science &Engineering
- Office Of The Director [968313] Funding Source: National Science Foundation
Paper-based microfluidic devices have recently garnered an increasing interest in the literature. The majority of these devices were produced by patterning hydrophobic zones in hydrophilic paper via photoresist or wax. Others were created by cutting paper using a laser. Here, we present a fabrication method for producing devices by simple craft-cutting and lamination, in a way similar to making an identification (ID) card. The method employs a digital craft cutter and roll laminator to produce laminated paper-based analytical devices (LPAD). Lamination with a plastic backing provides the mechanical strength for a paper device. The approach of using a craft cutter and laminator makes it possible to rapid-prototype LPAD with no more difficulty than producing a typical ID card, at very low cost. Devices constructed using this method have been exploited for simultaneous detection of bovine serum albumin (BSA) and glucose in synthetic urine with colorimetric assays. Both BSA and glucose are detectable at clinically relevant concentrations, with the detection limit at 2.5 mu M for BSA and 0.5 mM for glucose.
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