期刊
MICROFLUIDICS AND NANOFLUIDICS
卷 7, 期 2, 页码 217-226出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10404-008-0377-2
关键词
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资金
- University of Cincinnati Institute for Nanoscale Science and Technology
- National Institute of Occupational Safety and Health (NIOSH) Health Pilot Research Project Training Program
- University of Cincinnati Education and Research Center [T42/OH008432-04]
In this paper, we describe a simple passive microfluidic device with rectangular microchannel geometry for continuous particle filtration. The design takes advantage of preferential migration of particles in rectangular microchannels based on shear-induced inertial lift forces. These dominant inertial forces cause particles to move laterally and occupy equilibrium positions along the longer vertical microchannel walls. Using this principle, we demonstrate extraction of 590 nm particles from a mixture of 1.9 mu m and 590 nm particles in a straight microfluidic channel with rectangular cross-section. Based on the theoretical analysis and experimental data, we describe conditions required for predicting the onset of particle equilibration in square and rectangular microchannels. The microfluidic channel design has a simple planar structure and can be easily integrated with on-chip microfluidic components for filtration and extraction of wide range of particle sizes. The ability to continuously and differentially equilibrate particles of different size without external forces in microchannels is expected to have numerous applications in filtration, cytometry, and bioseparations.
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