期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 83, 期 1, 页码 38-43出版社
WILEY
DOI: 10.1111/sji.12385
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资金
- Capes
- UFRN Pharmaceutical Sciences Post-graduation Program
The subversion mechanisms employed by Helicobacter pylori (H.pylori) to escape from immune surveillance and to establish persistent infection are poorly understood. Growing evidence indicates that expression of HLA-G, a non-classical major histocompatibility complex molecule, negatively regulates immune responses in pathological conditions, including infectious diseases. In this context, we aimed to evaluate HLA-G expression in the gastric microenvironment of individuals harbouring H.pylori and to correlate it with histological variables. Fifty-four gastric specimens from patients harbouring H.pylori infection were evaluated by immunohistochemistry using anti-HLA-G monoclonal antibody. As a result, HLA-G expression was detected in 43 of 54 specimens harbouring H.pylori. The presence of HLA-G was significantly associated with milder colonization by H.pylori (P<0.02), milder inflammatory activity (P<0.02) and bacterium histological location in the gastric antrum. This study is the first to explore HLA-G expression in the context of bacterial infection. Whether the biological role of HLA-G during H.pylori infection is beneficial or hazardous for patients remains to be defined.
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