期刊
MICROELECTRONIC ENGINEERING
卷 88, 期 8, 页码 1660-1663出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2010.12.044
关键词
Superhydrophobicity; PMMA; X-ray diffraction; Droplet evaporation; Protein; Peptide; Residual; Crystallization
Polymeric (PMMA) ultrahydrophobic surfaces with contact angles up to about 170 degrees have been fabricated and used in the context of synchrotron radiation experiments on biological droplets. The different micro-fabrication processes included either an optical lithography phase followed by a plasma texturing one or a single step deep reactive ion etch attack. The drying of several biological solution droplets has been monitored. Room temperature evaporation experiments (lysozyme, lactalbumin, cytochrome C, doxorubicin and synthesized peptides) finally result in the formation of easily detachable hollow residuals because of the low interaction between the ultrahydrophobic substrate and the aqueous droplet while pilot experiments (bovine insulin) in a sitting-drop environment bring to the formation of well defined crystals. Recent results about in situ X-ray diffraction experiments by SAXS & WAXS (Small and Wide Angle X-ray Scattering) mu-beam techniques confirm that the presence of such surfaces influences the formation of crystal or fibril structures. These substrates represent indeed a suitable support to study biological and inorganic droplets in a near contact-free environment exploiting the homogeneous evaporation rate induced by the ultrahydrophobicity of the system. (C) 2010 Elsevier B.V. All rights reserved.
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