期刊
MICROELECTRONIC ENGINEERING
卷 88, 期 8, 页码 1718-1721出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2010.12.054
关键词
Polymer fibers; Scaffolds; Cell culture; Tissue engineering
资金
- Japanese Government [22710116, 22350104]
- European Commission [CP-FP 214566-2]
- Grants-in-Aid for Scientific Research [22350104, 22710116] Funding Source: KAKEN
We demonstrate a mass production amenable technology for the fabrication of polymer fibers that can be used as 3D scaffolds for cell culture and tissue engineering. As the first attempt, we used centrifugal melt spinning technique to fabricate fiber matrix of poly-lactic-co-glycolic acid (PLGA) which is a well-known biodegradable co-polymer. We then developed a solvent assisted centrifugal spinning technique to produce fiber matrix of polystyrene (PS) which has a relative high glass transition temperature comparing to that of PLGA. Both melt spinning and solvent assisted spinning techniques were studied with two types of commercial cotton-candy machines. Finally, the fabricated fibers were used as scaffolds for cell culture, showing application potentials for large volume cell proliferation. (C) 2010 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据