期刊
MICROELECTRONIC ENGINEERING
卷 85, 期 5-6, 页码 1289-1293出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mee.2008.02.004
关键词
cellular adhesion; cellular motility; PDMS; PDMS youngs's modulus; plastic and elastic deformations; substrate rigidity
The cellular adhesion and motility have direct implications in the tumoral-metastatic cells development or in the tissue engineering mechanisms for instance. Our work aims at knowing the impact of substrate mechanical properties on those adhesion and motility mechanisms by modifying bulk rigidity, surface energy and composition of a bio-compatible poly-di-methyl-siloxane (PDMS) substrate. We show how a wide range of PDMS rigidity can be obtained and how Ar/O-2-based plasmas turn PDMS surface to hydrophilic. A correlation between surface energy, bulk rigidity, cells adhesion and growth is finally shown. (C) 2008 Elsevier B.V. All rights reserved.
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