期刊
MICROCHIMICA ACTA
卷 178, 期 3-4, 页码 245-260出版社
SPRINGER WIEN
DOI: 10.1007/s00604-012-0831-4
关键词
Quartz crystal microbalance; Cantilever; Surface acoustic wave; Mass-sensitive; Bacteria; Virus; Food and water; Label-free detection; Surface immobilization; Cell growth; Signal amplification
Rapid and sensitive detection of pathogen is critical for public health, defense and security. Methods such as culture and immunoassays, though highly selective and accurate, are time-consuming and not sufficient for fast decision-making in many situations. Biosensors have been developed to meet the challenges in pathogen detection. This article reviews the development and application of electromechanical biosensors for pathogen detection. It covers the most commonly used electromechanical biosensor systems, specifically quartz crystal microbalances, cantilever sensors and surface wave acoustic sensors. Sensing principles, immobilization of biorecognition elements, and applications to the detection of pathogens in food and water samples are sequentially discussed.
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