期刊
MICROCHIMICA ACTA
卷 173, 期 3-4, 页码 331-335出版社
SPRINGER WIEN
DOI: 10.1007/s00604-011-0567-6
关键词
Micro/Nano-fluidic system; Micromixer; Protein preconcentration; Electrokinetic trapping
资金
- Agency for Defense [UD090078ID]
- Korean Government [KRF-2007-331-D00064, 2009-0065065]
- National Research Foundation of Korea [2009-0065065] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
An integrated micro/nano-fluidic system is presented for protein analysis. It is comprised of an integrated micromixer (IMM) and a preconcentrator with a separation column. The passive and planar type of IMM is based on an unbalanced split and the cross collision of the fluidic streams. The IMM can be easily fabricated and integrated to the microfluidic system. The preconcentrator has nanochannels formed by the electrical breakdown of polydimethylsiloxane (PDMS) membrane by applying a high electrical shock, but without any nano-lithography. The integrated microdevice was used for sample preparation (mixing with tagging molecules) and subsequent concentration of proteins. Proteins were electrokinetically trapped near the junction of the micro/nanochannels. We show a conceptual design and a simple microfluidic system for purposes of mixing and preconcentration.
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