期刊
MICROCHIMICA ACTA
卷 168, 期 3-4, 页码 347-354出版社
SPRINGER WIEN
DOI: 10.1007/s00604-009-0280-x
关键词
PAMAM-encapsulated Au-Pd/chitosan composite; Deoxyribonucleic acid (DNA); DNA damage; Antioxidant property; Sericin
资金
- National Natural Science Foundation of China [20775044]
- Natural Science Foundation of Shandong Province [Y2006B20]
Au-Pd bimetallic nanoparticles were prepared in the presence of an amine-terminated dendrimer of a fourth generation poly(amidoamine) type. A biosensor was fabricated by immobilizing dsDNA on a thin layer of a dendrimer-encapsulated bimetallic nanoparticles (Au-Pd) in a chitosan composite on a glassy carbon electrode. The biosensor was evaluated by square wave voltammetry for the determination of the oxidative damage of immobilized DNA and the antioxidant capacity of sericin. The biosensor is shown to be suitable for the rapid detection of DNA damage and the assessment of the antioxidant capacity of sericin.
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