期刊
MICROBIOLOGY-SGM
卷 158, 期 -, 页码 3014-3019出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.061192-0
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资金
- National Natural Science Foundation of China [30901415]
- Danish Strategic Research Council
- Danish Council for Independent Research
- Novo Nordisk Foundation
- Singapore Centre on Environmental Life Sciences Engineering (SCELSE)
Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.
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