期刊
MICROBIOLOGY-SGM
卷 156, 期 -, 页码 2621-2629出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.040147-0
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资金
- National Institutes of Health [R01 GM078589]
- Biotechnological and Biological Sciences Research Council [BB/E010741/1]
- UB Foundation
- BBSRC [BB/E010741/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E010741/1] Funding Source: researchfish
Mutants of Neurospora crassa unable to participate in vegetative hyphal fusion (anastomosis) were isolated and characterized. From this analysis, three genes, rcm-1, rco-1 and ham-5, were identified and shown to be required for hyphal fusion. The rcm-1 and rco-1 genes are homologues of the Saccharomyces cerevisiae SSN6 and TUP1 genes, which encode a dimeric transcription factor in yeast. We demonstrate that in N. crassa the rcm-1 and rco-1 genes are required for hyphal fusion and normal hyphal morphology, and influence both asexual and sexual development. The ham-5 gene encodes a 1686 amino acid protein with two putative WD40 domains, which might participate in protein-protein interactions. ham-5 deletion mutants had a reduced rate of hyphal extension and altered hyphal morphology, and were unable to produce the conidial anastomosis tubes that are required for hyphal fusion during colony initiation.
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