期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 73, 期 1, 页码 134-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.00034-08
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- NIEHS NIH HHS [P30 ES002109, 5-R01-ES015818, R01 ES015818] Funding Source: Medline
- NIGMS NIH HHS [5-F32-GM078966, F32 GM078966] Funding Source: Medline
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES015818, P30ES002109] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [F32GM078966] Funding Source: NIH RePORTER
DNA repair and DNA damage tolerance machineries are crucial to overcome the vast array of DNA damage that a cell encounters during its lifetime. In this review, we summarize the current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions. TLS aids in resistance to DNA damage, presumably by restarting stalled replication forks or filling in gaps that remain in the genome due to the presence of DNA lesions. One consequence of this process is the potential risk of introducing mutations. Given the role of these translesion polymerases in mutagenesis, we discuss the significant regulatory mechanisms that control the five known eukaryotic translesion polymerases: Rev1, Pol zeta, Pol kappa, Pol eta, and Pol (sic).
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