期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 72, 期 1, 页码 54-+出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.00020-07
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- PHS HHS [R01 A14911, R03 A168502] Funding Source: Medline
Enormous efforts have been made to produce a protective vaccine against human immunodeficiency virus type 1; there has been little success. However, the identification of broadly neutralizing antibodies against epitopes on the highly conserved membrane-proximal external region (MPER) of the gp4l envelope protein has delineated this region as an attractive vaccine target. Furthermore, emerging structural information on the MPER has provided vaccine designers with new insights for building relevant immunogens. This review describes the current state of the field regarding (i) the structure and function of the gp41 MPER; (ii) the structure and binding mechanisms of the broadly neutralizing antibodies 2F5, 4E10, and Z13; and (iii) the development of an MPER-targeting vaccine. In addition, emerging approaches to vaccine design are presented.
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