期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 58, 期 11, 页码 643-648出版社
WILEY
DOI: 10.1111/1348-0421.12197
关键词
chicken IgY; edema disease; Shiga toxin 2e
资金
- Japan Society for the Promotion of Science KAKENHI Grant [24590539]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [24590539] Funding Source: KAKEN
Chicken egg yolk immunoglobulin (IgY) against Shiga toxin 2e (Stx2e), a major cause of swine edema disease, was prepared to evaluate its possible clinical applications. The titer of Stx2e-specific IgY in egg yolk derived from three chickens that had been immunized with an Stx2e toxoid increased 2 weeks after primary immunization and remained high until 90 days after this immunization. Anti-Stx2e IgY was found to neutralize the toxicity of Stx2e by reacting with its A and B subunits, indicating that IgY is a cost-effective agent to develop for prophylactic foods or diagnosis kits for edema disease.
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