期刊
MICROBIOLOGICAL RESEARCH
卷 169, 期 7-8, 页码 541-546出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.micres.2013.11.002
关键词
Streptococcus suis serotype 2; NisKR; Virulence
类别
资金
- National Natural Science Foundation of China (NSFC) [31101844]
- Ministry of Science and Technology of China [2012CB518803]
- Fundamental Research Funds for the Central Universities
Two-component signal-transduction systems (TCSTSs) may regulate some virulence factors in response to external stimuli, and thus allowing Streptococcus. suis serotype 2 to interact with the host, promote survival, and cause disease. Here, a mutant of the NisKR TCSTS had attenuated virulence in vitro, as exemplified by lowered hemolytic activity, reduced adherence to epithelial cells, increased elimination by macrophages, and decreased resistance to killing by neutrophils. Results also showed that this system is important for the ability of S. suis serotype 2 to survive and proliferate in an in vivo mouse model. Thus, the NisKR system plays a significant role in pathogenesis, both in colonization and invasive disease. Crown Copyright (C) 2013 Published by Elsevier GmbH. All rights reserved.
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