期刊
MICROBIOLOGICAL RESEARCH
卷 164, 期 2, 页码 191-195出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.micres.2006.11.012
关键词
Cicerfuran; 2-Arylbenzofurans; Stilbenes; Antifungal; Antibacterial
类别
Cicerfuran, 2-(2-methoxy-4,5-methylenedioxyphenyl)-6-hydroxybenzofuran, is an antifungal phytoalexin previously isolated from the roots of chickpea, Cicer spp. The synthesis of cicerfuran, five 2-arylbenzofuran analogues and nine stilbene intermediates was reported recently. The antimicrobial activities of these compounds were evaluated against two species of bacteria, Bacillus subtilis and Pseudomonas syringae, and four species of filamentous fungi, Aspergillus niger, Botrytis cinerea, Cladosporium herbarum and Monilinia aucuporiae. Stilbenes with a free hydroxyl. group were active against both bacteria and fungi with MICs in the range 25-100 mu g/ml. Cicerfuran was the only 2-arylbenzofuran that showed antimicrobial activity with MICs as low as 25 mu g/ml. Some aspects of the structure-activity relationship are discussed. (C) 2007 Elsevier GmbH. All rights reserved.
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