期刊
MICROBIAL PATHOGENESIS
卷 46, 期 1, 页码 6-12出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2008.10.007
关键词
Mycobacterium avium complex; Virulence; Clinical isolates; Immunocompetent humans; Pulmonary disease
资金
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare (Research on Emerging and Reemerging Infectious Diseases
- The Japan Health Sciences Foundation
- The United States-Japan Cooperative Medical Science Program
Mycobacterium avium complex (MAC) disease has been increasing worldwide not only in immunocompromised but also in immunocompetent humans. However, the relationship between mycobacterial strain virulence and disease progression in immunocompetent humans is unclear. In this study, we isolated 6 strains from patients with pulmonary MAC disease. To explore the virulence, we examined the growth in human THP-1 macrophages and pathogenicity in C57BL/6 mice. We found that one strain, designated 198, which was isolated from a patient showing the most progressive disease, persisted in THP-1 cells. In addition, strain 198 grew to a high bacterial load with strong inflammation in mouse lungs and spleens 16 weeks after infection. To our knowledge, strain 198 is the first isolated MAC strain that exhibits hypervirulence consistently for the human patient, human macrophages in vitro, and even for immunocompetent mice. Other strains showed limited survival and weak virulence both in macrophages and in mice, uncorrelated to disease progression in human patients. We demonstrated that there is a hypervirulent clinical MAC strain whose experimental virulence corresponds to the serious disease progression in the patients. The existence of such strain suggests the involvement of bacterial virulence in the pathogenesis of pulmonary MAC disease in immunocompetent status. (c) 2008 Elsevier Ltd. All rights reserved.
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