期刊
MICROBIAL PATHOGENESIS
卷 46, 期 2, 页码 80-87出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2008.10.013
关键词
Propionibacterium acnes; Sarcoidosis; Cell invasiveness; Serotype; Trigger factor
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [18390112]
- Grants-in-Aid for Scientific Research [18390112] Funding Source: KAKEN
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Propionibacterium acnes is the only microorganism so far isolated from sarcoid lesions. To examine whether P. acnes isolates from sarcoid tissues differ from those obtained from non-sarcoid tissues, we studied cell invasiveness, serotype, and polymorphisms of the P. acnes trigger factor protein and the two invasion-associated proteins (named PAmce and PAp60) in 35 P. acnes isolates from sarcoid lymph nodes and 127 isolates from non-sarcoid tissues. Most of the serotype I isolates (79/112; 71%), but none of the serotype 11 isolates (0/50) were cell-invasive. Two prominent types of trigger factors, one with and one without a 15 amino acid-residue deletion, corresponded to serotype 11 and serotype 1, respectively. Non-invasive isolates had genomic mutations that caused more than one amino acid change in either the PAmce or PAp60 gene, with four exceptional isolates. R acnes was finally classified into nine isotypes, and isolates obtained from sarcoid and non-sarcoid tissue did not differ. Although the finding did not link P. acnes to sarcoidosis, the present study clarified the cell invasiveness of R acnes and the close correlation of cell invasiveness to the serotype and genotype of the two invasion-associated P. acnes genes. (C) 2008 Elsevier Ltd. All rights reserved.
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