期刊
MICROBES AND INFECTION
卷 16, 期 6, 页码 522-527出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2014.03.005
关键词
Pneumocystis; PCP; MyD88; Innate immunity; TLR
资金
- Intramural Research Program of the NIH Clinical Center
- National Cancer Institute, National Institutes of Health
- National Institute of Allergy and Infectious Disease, National Institutes of Health [HHSN261200800001E]
To determine if myeloid differentiation factor 88 (MyD88), which is necessary for signaling by most TLRs and IL-1Rs, is necessary for control of Pneumocystis infection, MyD88-deficient and wild-type mice were infected with Pneumocystis by exposure to infected seeder mice and were followed for up to 106 days. MyD88-deficient mice showed clearance of Pneumocystis and development of anti-Pneumocystis antibody responses with kinetics similar to wild-type mice. Based on expression levels of select genes, MyD88-deficient mice developed immune responses similar to wild-type mice. Thus, MyD88 and the upstream pathways that rely on MyD88 signaling are not required for control of Pneumocystis infection. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
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