期刊
MICROBES AND INFECTION
卷 16, 期 9, 页码 727-734出版社
ELSEVIER
DOI: 10.1016/j.micinf.2014.07.005
关键词
mTOR; Autophagy; Acute lung injury
资金
- General Project [81370142]
- National Natural Science Foundation of China [81130001]
- National Clinical Research Center of China for Respiratory Disease
The mammalian target of rapamycin (mTOR) is a central regulator of many major cellular processes including protein and lipid synthesis and autophagy, and is also implicated in an increasing number of pathological conditions. Emerging evidence suggests that both mTOR and autophagy are critically involved in the pathogenesis of pulmonary diseases including acute lung injury (ALI). However, the detailed mechanisms of these pathways in disease pathogenesis require further investigations. In certain cases within the same disease, the functions of mTOR and autophagy may vary from different cell types and pathogens. Here we review recent advances about the basic machinery of mTOR and autophagy, and their roles in ALI. We further discuss and propose the likelihood of cell type- and pathogen-dependent functions of these pathways in ALI pathogenesis. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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