期刊
MICROBES AND INFECTION
卷 15, 期 1, 页码 28-36出版社
ELSEVIER
DOI: 10.1016/j.micinf.2012.10.007
关键词
Schistosoma mansoni; Vaccine; Alum; CpG-ODN; Parasite
资金
- CNPq
- INCT-DT/CNPq
- Ripag/CPqRR-Fiocruz
- CPqRR/Fiocruz
- PIBIC/CNPq
- PQ/CNPq
In schistosomiasis, the current control strategy does not prevent reinfection, therefore, vaccine strategies are essential to combat the Schistosoma mansoni. The efficacy vaccine depends on parasite stage and effective adjuvant. We have recently demonstrated that S. mansoni schistosomula tegument (Smteg) is able to activate dendritic cells up regulate CD40 and CD86 molecules and induce a partial protection in mice (43-48%) when formulated with Freund's adjuvant. In this study we evaluated the ability of Smteg + alum or Smteg + alum + CpG-ODN to induce protection in mice. Our results demonstrate that Smteg + alum + CpG-ODN induced a partial reduction in worm burden (43.1%), reduction in the number of eggs eliminated in the feces. The protective response was associated with a predominant Th 1 type of immune response, with increased production of specific IgG2c, IFN-gamma and TNF-alpha, B cells proliferation and CD4 cells and macrophages activation. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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