期刊
MICROBES AND INFECTION
卷 14, 期 14, 页码 1284-1292出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2012.05.011
关键词
ATP; NAD; P2X7; Danger signals; Tregs
资金
- Inserm
- Association Francaise contre les Myopathies
- Deutsche Forschungsgemeinschaft
Endogenous danger signals released during cell damage contribute to alert the immune system. Typically, their release results in the activation and maturation of innate immune cells, and the production of pro-inflammatory cytokines. In addition, extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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