期刊
MICROBES AND INFECTION
卷 14, 期 7-8, 页码 563-572出版社
ELSEVIER
DOI: 10.1016/j.micinf.2012.01.011
关键词
Ubiquitin; NF-kappa B; Inflammation; Cytokine; Immunity; Apoptosis
资金
- MEXT
- JSPS, Japan
- Grants-in-Aid for Scientific Research [22117006, 23390070, 23657075] Funding Source: KAKEN
LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-kappa B pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-kappa B by LUBAC and the diseases associated with this process are the focus of this review. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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