Regulation between survival, persistence, and elimination of intracellular mycobacteria: a nested equilibrium of delicate balances

This review elaborates on recent insights gained on the dynamic aspects of interactions between pathogen and the host intracellular machinery in tuberculosis infection. In addition we will also discuss the utility of adopting a systems biology approach, both for a better understanding of TB biology, and for the development of more effective ways for disease management. (c) 2010 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.