Autophagy facilitates an IFN-γ response and signal transduction

Autophagy, that is directly triggered by invaded pathogens and indirectly triggered by IFN-gamma, acts as a defense by mediating intracellular microbial recognition and clearance. In addition, autophagy contributes to inflammation by facilitating an IFN-gamma response and signal transduction. For immune escape, downregulated autophagy may be a strategy used by microbes. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.