期刊
MICROBES AND INFECTION
卷 12, 期 2, 页码 89-98出版社
ELSEVIER
DOI: 10.1016/j.micinf.2009.10.002
关键词
Pathogenesis; Enterotoxins; Enterotoxigenic Escherichia coli; Escherichia coli vaccines; Genomics
资金
- BLRD VA [I01 BX001469] Funding Source: Medline
Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in developing countries, and perennially the most common cause of traveller's diarrhea. ETEC constitute a diverse pathotype that elaborate heat-labile and/or heat-stable enterotoxins. Recent molecular pathogenesis studies reveal sophisticated pathogen-host interactions that might be exploited in efforts to prevent these important infections. While vaccine development for these important pathogens remains a formidable challenge, extensive efforts that attempt to exploit new genomic and proteomic technology platforms in discovery of novel targets are presently ongoing. Published by Elsevier Masson SAS.
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