期刊
MICROBES AND INFECTION
卷 12, 期 12-13, 页码 1079-1084出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2010.06.011
关键词
Influenza virus; Vesicular trafficking; Ribonucleoprotein; Fluorescence in situ hybridization
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japanese Society for the Promotion of Science (JSPS)
- Kitasato University
- Grants-in-Aid for Scientific Research [22790438] Funding Source: KAKEN
The genome of influenza type A virus consists of single-stranded RNAs of negative polarity Progeny viral RNA (vRNA) replicated in the nucleus is nuclear-exported, and finally transported to the budding site beneath the plasma membrane However, the precise process of the membrane targeting of vRNA is unclear although viral proteins and cytoskeleton are thought to play roles Here we have visualized the translocation process of progeny vRNA using fluorescence in situ hybridization method Our results provide an evidence of the Involvement of vesicular trafficking in membrane targeting of progeny vRNA independent of that of viral membrane proteins (C) 2010 Institut Pasteur Published by Elsevier Masson SAS All rights reserved
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