期刊
MICROBES AND INFECTION
卷 11, 期 5, 页码 594-598出版社
ELSEVIER
DOI: 10.1016/j.micinf.2009.04.002
关键词
FOXP3; Regulatory T cell; Th17
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI048779] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI048779-05, R01 AI048779] Funding Source: Medline
CD4 T cell lineages are marked by the signature transcription factor each lineage expresses. For example, regulatory T cells (Tregs) are characterized by expression of FOXP3, which is either induced during thymic development for natural Tregs (nTregs), or in the periphery in the presence of TGF-beta and retinoic acid for induced Tregs (iTreg). Interestingly, recent work has shown that the signature transcription factor for Th17 cells, ROR gamma t, is also induced by TGF-beta, thus linking the differentiation of the Treg and Th17 lineages. In the absence of a second signal from a proinflammatory cytokine, FOXP3 can inhibit RCR gamma t function and drive Treg differentiation. However, when the cell also receives a signal from a proinflammation cytokine (e.g., IL-6), FOXP3 function is inhibited and the Th17 differentiation pathway is induced. Therefore, it is the balance between FOXP3 and ROR gamma t function that determines CD4 T cell fate and the type of immune response that will be generated. (C) 2009 Elsevier Masson SAS. All fights reserved.
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