期刊
MICROBES AND INFECTION
卷 11, 期 3, 页码 413-418出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.01.002
关键词
Perfringens; Septicum; alpha-Toxin; Pathogenesis; Myonecrosis
资金
- Australian National Health and Medical Research Council
- Australian Postgraduate Award
Clostridium perfringens and Clostridium septicum are the most common causes of clostridial myonecrosis or gas gangrene. Although they mediate a similar disease pathology, they elaborate functionally very different alpha-toxins. We used a reciprocal complementation approach to assess the contribution of the primary toxin of each species to disease and found that C. perfringens a-toxin (PLC) was able to mediate the gross pathology of myonecrosis even in a C. septicum background, although it could not induce vascular leukostasis. Conversely, while C. septicum alpha-toxin restored some virulence to a C. perfringens plc mutant, it was less active than in its native background. (C) 2009 Elsevier Masson SAS. All fights reserved.
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