期刊
MICROBES AND INFECTION
卷 11, 期 1, 页码 74-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2008.10.010
关键词
Animal model; Salmonella Enteritidis; Reactive arthritis; Synovitis; Enteritis; Joint inflammation
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina [PIP-5534]
- Agencia Nacional de Promocion a la Ciencia y la Tecnologia, Argentina [ANPCyT PICT 2003-13366, PICT 200600407]
- Secretaria de Ciencia y Tecnica de la Universidad de Buenos Aires, Argentina [UBACyT M009]
Reactive arthritis (ReA) is a sterile inflammation triggered by a distal mucosal infection, which suggests a contribution from bacterial products. Investigation on the pathogenesis of ReA is difficult because of the limited studies that can be performed in humans; therefore the availability of animal models is crucial. We hereby describe a murine model for studying the early stages of Salmonella-induced ReA. BALB/c mice infected by the natural route with a sublethal dose of S. Enteritidis showed long lasting gut inflammation, synovitis in the knee joint and a significant increase of CD4+ lymphocytes in the draining popliteal lymph nodes. S. Enteritidis infection induced histological changes in intact knees and exacerbated inflammation in previously damaged joints. Experiments performed with S. Enteritidis Delta invG mutant suggest that the proinflammatory signalling mediated by Salmonella TTSS-1 in the gut is required for the induction of joint sequelae. Since this model is highly reproducible and easy to perform, it provides great potential for investigating both host and bacterial contributions to the early stages of ReA. (c) 2008 Elsevier Masson SAS. All rights reserved.
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