期刊
MICROBES AND INFECTION
卷 11, 期 6-7, 页码 637-645出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2009.03.009
关键词
P. gingivalis; Host-pathogen interactions; Innate immunity; Inflammation; Immune evasion
资金
- U.S. Public Health Service [DE015254, DEO 18292]
- NIH
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE015254] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE018292] Funding Source: NIH RePORTER
This review summarizes and discusses virulence mechanisms whereby Porphyromonas gingivalis can persist in the oral cavity. It is proposed that the virulence of P. gingivalis is dependent, at least in part, upon its ability to establish a complex host-pathogen molecular crosstalk which subverts innate immunity. The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche. (C) 2009 Elsevier Masson SAS. All rights reserved.
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