期刊
MICROBES AND INFECTION
卷 10, 期 4, 页码 447-451出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2007.12.012
关键词
malaria; rosetting; multiplication rate; Saimiri sciureus monkey; virulence
Severe Plasmodium falciparum malaria in African children is associated with high peripheral parasite densities and high rate of rosette-forming parasites. To explore the relationship between rosette formation and parasite density in vivo, we compared the multiplication rate of a rosette-forming variant (varO) of the Palo Alto line with a sibling non-rosetting variant (varR) in splenectomized Saimiri monkeys. The multiplication rate of varO parasites was 1.5-fold higher than that of the varR variant. This indicates that rosetting is indeed associated with high parasite multiplication efficiency in vivo and, as such, may contribute to the high parasite densities observed in severe malaria. (C) 2008 Elsevier Masson SAS. All rights reserved.
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