期刊
MICROBES AND INFECTION
卷 10, 期 9, 页码 953-959出版社
ELSEVIER
DOI: 10.1016/j.micinf.2008.07.038
关键词
Th1; Th2; IL-4; IL-13; Leishmania
资金
- Wellcome Trust
- Royal Society
- E.P.S.R.C. sponsored Research Fellow
While control of intracellular pathogens, such as the protozoan Leishmania, is dependent oil the,generation of type-1 immune responses, the role of T helper 2 cytokines in the disease process is more controversial. Traditionally these cytokines were perceived as counter-regulating type-1 responses and promoting disease exacerbation. Nevertheless a substantial body of evidence now exists suggesting that the development of effective type-1 immunity can involve the significant involvement of the Th2 cytokines IL-4 and IL-13. This article reviews, using Leishmania species in particular, the circumstances under which these cytokines can promote protective type-1 immunity. (C) 2008 Elsevier Masson SAS. All rights reserved.
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