期刊
MICRO & NANO LETTERS
卷 13, 期 12, 页码 1688-1692出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2018.5267
关键词
drug delivery systems; nanofabrication; nanomedicine; membranes; biomedical materials; ibu-loaded fibrous membranes; ket-loaded fibrous membranes; fibre-based delivery systems; water-soluble drugs; drug formulations; in-vitro drug release tests; drug-loaded ultrafine starch-PEO fibres
资金
- Natural Science Foundation of Zhejiang Province [LY17E030009]
In this work, the authors prepared drug-loaded ultrafine starch/polyethylene oxide (PEO) fibres through centrifugal spinning, which use the poorly water-soluble drugs ibuprofen (ibu) and ketoprofen (ket) as model drugs. The obtained fibres were treated by acetic acid/glutaraldehyde solution (1/1, v/v) for 12 h at 40 degrees C, in order to remove residual sodium hydroxide in fibres and improve the water stability. The morphology, chemical structures, and mechanical properties of obtained fibres were investigated. In-vitro drug release tests revealed that more than 75% of loaded drugs could be released from fibrous membranes without initial burst release (>80% in the first 2 h). The ibu-loaded fibrous membranes showed a sustained release period as long as 24 h, while the ket-loaded fibrous membranes could release more than 48 h. These fibre-based delivery systems are therefore proposed to be good candidate drug formulations, especially for improving solubility and bioavailability of poorly water-soluble drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据