期刊
MICRO & NANO LETTERS
卷 8, 期 12, 页码 906-908出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2013.0630
关键词
biomedical materials; diseases; drug delivery systems; drugs; etching; microorganisms; needles; porous materials; skin; titanium; microfabrication; Ti; size 20 mum; distance 800 mum; disease treatment; rats; insulin injection; skins; piercing; shear forces; microholes; organisms; wet etching; cutting; porous metal microneedles; drug delivery; porous titanium microneedle testing; porous titanium microneedle fabrication
资金
- National Natural Science Foundation of China [51035005]
- Science and Technology Department of Shanghai [11DZ2290203, 11JC1405700]
- Program for New Century Excellent Talents in University
Porous metal microneedles were fabricated by an incorporated process of cutting and wet etching. Each microneedle is comprised of many connecting microholes that can deliver drugs into organisms conveniently and efficiently. The microneedle height is larger than 400 m, the pitch distance is about 800 m and the microholes in each microneedle are about 20 m in diameter. In force testing, the microneedles could resist large shear forces and pierce into skins easily; in the in vivo experiment, the insulin was efficiently injected into rats by a patch of the microneedles. The testing and the experiment demonstrated that the microneedles could deliver drugs into organisms to treat diseases without fracture.
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