期刊
MICRO & NANO LETTERS
卷 8, 期 11, 页码 796-800出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2013.0461
关键词
biochemistry; drug delivery systems; nanoparticles; polymer blends; toxicology; nanomedicine; subacute oral toxicity; poly(lactic acid)-b-Pluronic-b-poly(lactic acid) nanoparticles; PLA-P85-PLA nanoparticles; drug delivery application; acute oral toxicity; mice; blood samples; biochemical analysis; histopathological analysis; time 14 day; time 28 day
资金
- National Natural Science Foundation of China [81060264, 21264009]
- Jinggang Star Cultivation Program for Young Scientists of Jiangxi Province [2008DQ01600]
- Ministry of Personnel of China [[2006] 164, [2010]412]
- Department of Education of Jiangxi Province [GJJ13564]
The objective of the present reported study was to evaluate the oral toxicity of poly (lactic acid)-b-Pluronic-b-poly (lactic acid) (PLA-P85-PLA) nanoparticles (NPs) so as to demonstrate their applicability for drug delivery applications. In acute oral toxicity studies, the animals were fed with 0.4 ml PLA-P85-PLA NPs solution in different concentrations (low concentration: 20 mg/l, intermediate concentration: 100 mg/l and higher concentration: 500 mg/l) for 14 days; no deaths or treatment related complications were observed even in the higher concentration treatment. In case of the subacute oral toxicity test, the NPs were administered orally to mice for a period of 28 days. At the end of the study, blood samples were collected for biochemical analysis. For histopathological analysis, organs of the animals were weighed and processed. All the animals survived during the study, with no significant changes in clinical signs, body weight, feed consumption, biochemistry parameters, organ weights and histopathological findings. These results demonstrate that PLA-P85-PLA NPs produced no treatment related toxicity in mice following oral administration, thus, they can be exploited for potential therapeutic applications.
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