期刊
MICRO & NANO LETTERS
卷 7, 期 12, 页码 1313-1315出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/mnl.2012.0633
关键词
-
资金
- National Natural Science Foundation of China [51035005]
- Science and Technology Department of Shanghai [11JC1405700, 11DZ2290203]
- Shanghai Jiao Tong University Wuxi Research Institute Foundation [2011JDZX017]
Metal microneedles are fabricated by the process of cutting and electrochemical corrosion. The fabricated microneedles are 400 mm in length, 700 mm in space and have sharp tapered tips. In a force test, these microneedles could penetrate an artificial skin and a rat's skin well and safely. In a vitro transdermal drug delivery test, the amount of the permeated flux of calcein and of the bovine serum albumin through the treated rat skin increased by 35 and six times than that on the intact skin, respectively.
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