期刊
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
卷 31, 期 2, 页码 101-106出版社
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/mf.2009.31.2.1338414
关键词
Antiepileptic drugs; In vivo testing; Acute seizure model; Electroshock
The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the conventional and threshold MES test experimental procedures, the factors affecting experimental data (laboratory conditions, administration vehicles and drug formulations, time after drug administration, and stimulus duration and site of stimulation) and the assessment of anticonvulsant activity are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据