期刊
METALLOMICS
卷 3, 期 3, 页码 271-279出版社
OXFORD UNIV PRESS
DOI: 10.1039/c0mt00064g
关键词
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资金
- [ES R01-10563]
- [ES R01-07331]
- [ES T32-007028]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [F31ES017196, R01ES007331, T32ES007028, R01ES010563] Funding Source: NIH RePORTER
Neurodegeneration is characterized by the cell death or loss of structure and/or function of neurons. Many neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease AD) are the result of neurodegenerative processes. Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms. In this review, we discuss the role of metals in neurodegenerative diseases with emphasis on the utility of Caenorhabditis elegans (C. elegans) genetic models in deciphering mechanisms associated with the etiology of PD and AD.
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