期刊
METABOLOMICS
卷 10, 期 3, 页码 414-424出版社
SPRINGER
DOI: 10.1007/s11306-013-0595-9
关键词
Metabolomics; Metabolite; Biomarker; Acute coronary syndrome
资金
- Instituto de Salud Carlos III [FIS PI070537, FIS PI080970, FIS PI080920, RD07/0064/0023, PI11/02239, PI11/001401, CP09/00229]
- Fondo de Investigacion Sanitaria de Castilla la Mancha (FISCAM) [PI2008/08, FISCAM PI2008/52]
- Redes Tematicas de Investigacion Cooperativa (FONDOS FEDER) [RD06/0014/1015, RD12/0042/0071]
Discovery of new biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Recent advances in metabolomic technologies have drastically enhanced the possibility of improving the knowledge of its physiopathology through the identification of the altered metabolic pathways. In this study, analyses of peripheral plasma from non-ST segment elevation ACS patients and healthy controls by gas chromatography-mass spectrometry (GC-MC) permitted the identification of 15 metabolites with statistical differences (p < 0.05) between experimental groups. Additionally, validation by GC-MC and liquid chromatography-MC permitted us to identify a potential panel of biomarkers formed by 5-OH-tryptophan, 2-OH-butyric acid and 3-OH-butyric acid. This panel of biomarkers reflects the oxidative stress and the hypoxic state that suffers the myocardial cells and consequently constitutes a metabolomic signature of the atherogenesis process that could be used for early diagnosis of ACS.
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