期刊
METABOLOMICS
卷 7, 期 3, 页码 329-343出版社
SPRINGER
DOI: 10.1007/s11306-010-0270-3
关键词
Metabolomics; Cancer; Metabolite profiling; NMR; Mass spectrometry; Bioinformatics
资金
- NIH (National Institutes of Health) NCI (National Cancer Institute) [R01CA120170]
- NIH NIDDK (National Institutes of Diabetes and Digestive and Kidney Diseases) [R37 DK42412]
It is well known that significant metabolic change take place as cells are transformed from normal to malignant. This review focuses on the use of different bioinformatics tools in cancer metabolomics studies. The article begins by describing different metabolomics technologies and data generation techniques. Overview of the data pre-processing techniques is provided and multivariate data analysis techniques are discussed and illustrated with case studies, including principal component analysis, clustering techniques, self-organizing maps, partial least squares, and discriminant function analysis. Also included is a discussion of available software packages.
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