期刊
METABOLOMICS
卷 5, 期 3, 页码 330-335出版社
SPRINGER
DOI: 10.1007/s11306-009-0158-2
关键词
Alternariol; Mycotoxin; Metabolomics; Stagonospora nodorum; Pathogen
资金
- Grains Research and Development Corporation
- Australian Postgraduate Award
A recent comparative proteomics study identified the short-chain dehydrogenase (Sch1) as being required for asexual sporulation (Tan et al. Eukaryotic Cell 7:1916-1929, 2008). Metabolite profiling was undertaken on the mutant strains of Stagonospora nodorum lacking the Sch1 gene to help elucidate its role. Gas chromatography-mass spectrometry of the polar metabolites in the Sch1 mutants identified a secondary metabolite at a 200-fold greater concentration than observed in the wild-type strains. Comparative analysis of the secondary metabolite and the mycotoxin alternariol using ESI-MS/MS confirmed the identity of the compound as alternariol. This is the first report to confirm the presence of a mycotoxin in S. nodorum and compelling the field to consider the health implication of this disease.
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