期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 63, 期 2, 页码 242-249出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2013.11.012
关键词
Uric acid; Laparoscopic sleeve gastrectomy (LSG); Roux-Y gastric bypass (RYGB); Morbid obesity; Adolescents
资金
- Federal Ministry of Education and Research (BMBF), Germany [01E01001]
- National Institutes of Health sponsored Adolescent Gastric Bypass and Diabetic Precursors [NIH R03DK068228]
Objective. Serum uric acid (sUA) is believed to contribute to the pathogenesis of metabolic comorbidities like hypertension, insulin-resistance (IR) and endothelial dysfunction (EDF) in obese children. The present pilot study investigated the association between sUA concentrations and loss of body weight following laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y-gastric bypass (RYGB) in severely obese adolescents. Materials/Methods. 10 severely obese adolescents underwent either LSG (n = 5) or RYGB (n = 5). 17 normal weight, healthy, age- and gender-matched adolescents served as a normal weight peer group (NWPG). Pre- and 12 months postoperatively, sUA and relevant metabolic parameters (glucose homeostasis, transaminases, lipids) were compared. Results. Preoperatively, sUA was significantly elevated in patients with severe obesity compared to NWPG. Twelve months after LSG and RYGB, a significant decrease in sUA, EMI, CVD risk factors, hepatic transaminases, and HOMA-IR was observed. Reduction in SDS-BMI significantly correlated with changes in sUA. Conclusions. sUA levels and metabolic comorbidities improved following bariatric surgery in severely obese adolescents. The impact of changes in sUA on long-term clinical complications of childhood obesity deserves further study. (C) 2014 Elsevier Inc. All rights reserved.
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