期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 62, 期 11, 页码 1597-1606出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2013.07.005
关键词
Metabolic syndrome; Early menarche; Late menarche; Oligomenorrhea; Cardiometabolic abnormalities
资金
- American Heart Association (National) [9750129N, NIH-HL62394]
- Lipoprotein Research Fund of the Jewish Hospital of Cincinnati
- Charlotte M. Schmidlapp Women's Scholars Award
Objective. We determined whether simple, clinical information on late and early menarche could help identify adult women with metabolic syndrome (MetS) and oligomenorrhea. Materials/Methods. We carried out a 26-year prospective follow-up of 272 suburban schoolgirls from ages 5-22 to 30-46. Results. Early menarche (<= 10 years, 5.2% of girls) and late menarche (>= 16 years, 6.7% of girls) were both associated with oligomenorrhea (>= 42 days) in adulthood, 29% and 11%, vs. 5% for normal menarche (11-15 years), p =.004. Early menarche was characterized by high childhood BMI (LS mean +/- SE: 21.2+1.0 kg/m(2)) and by high childhood and adult MetS (15%, 36%). Girls with late menarche had the lowest childhood BMI (18.1 +/- 1.0), no childhood MetS, and the highest adult MetS (47%). Increasing age at menarche was associated with uniformly decreasing childhood BMI and MetS, but with a U-shaped pattern of BMI (p =.05), MetS (p =.008), and oligomenorrhea (p =.02) in adulthood. Change to MetS from median ages 13 to 38 was associated with early-late menarche (OR = 3.11, 95% CI 1.37-7.07, p =.007). MetS in adulthood was associated with childhood MetS (OR = 8.03, 95% CI 2.57-25.08, p =.0003) and with early-late menarche (OR =3.43, 95% CI 1.44-8.15, p =.005). Conclusions. Menarche age had a curvilinear ('U' shaped) relationship with MetS and oligomenorrhea in adulthood. Late menarche and early menarche are risk factors for adult oligomenorrhea, MetS, and cardiometabolic abnormalities. Girls with early (<= age 10) and with late menarche (>= 16) represent a group at high risk for adult cardiometabolic abnormalities and oligomenorrhea that is easily identifiable by physicians. (C) 2013 Elsevier Inc. All rights reserved.
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