期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 60, 期 5, 页码 735-739出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2010.07.022
关键词
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资金
- Ministry of Health, Labor, and Welfare of Japan [H20-hepatitis-008]
- Grants-in-Aid for Scientific Research [23590470] Funding Source: KAKEN
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common features. Both are associated with visceral obesity, type 2 diabetes mellitus, metabolic syndrome, and insulin resistance. However, the relationship between NAFLD and CKD is poorly understood. We examined the prevalence of and risk factors for CKD in patients with NAFLD. We analyzed 174 Japanese patients With liver biopsy proven NAFLD using a cross-sectional design. Chronic kidney disease was defined as estimated glomerular filtration. rate less than 60 mL/min per 1.73 m(2) and/or overt proteinuria. Of 174 NAFLD patients, 92 (53%) exhibited histologic characteristics of nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD; and 82 (47%) had non-NASH NAFLD. Chronic kidney disease was present in 24 (14%) of 174 NAFLD patients. the prevalence:of CKD was significantly higher in NASH patients (19 of 92; 21%) than non-NASH patients (5 of 82; 6%). The presence of CKD was associated with a higher body mass index and the presence of hypertension and NASH. Our results demonstrated a high prevalence of CKD among patients with NASH. (C) 2011 Elsevier Inc. All rights reserved.
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