期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 59, 期 11, 页码 1633-1641出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2010.03.013
关键词
-
资金
- Peter Snell Doctoral Scholarship in Public Health and Exercise Science
It has been speculated that dietary carbohydrate restriction is solely responsibly for mobilization of endogenous lipid stores, elevation of plasma free fatty acid (FFA) concentration, and an associated reduction in insulin sensitivity seen in starvation and low-carbohydrate diets. In 6 healthy men, dietary carbohydrate was eliminated but gluconeogenic substrate supply was maintained by 3 days of very low-carbohydrate/high-protein (HPLC) diet. Results were compared with 3-day starvation and 3-day mixed-carbohydrate diet. Intramyocellular lipid (IMCL) concentration was measured by H-1 magnetic resonance spectroscopy, and insulin sensitivity was determined by intravenous glucose tolerance test. Fasting plasma glucose was significantly reduced ([starvation] 3.5 +/- 0.3 vs [HPLC] 4.2 +/- 0.4 and [mixed] 4.5 +/- 0.3 mmol L-1 P < .01), and IMCL to water ratio (25.6 +/- 5.9 vs 13.6 +/- 6.1 and 13.6 +/- 3.3 x 10(-3) P < .01) and fasting FFA (1179 +/- 294 vs 387 +/- 232 and 378 +/- 120 mu mol L-1 P < .05) were significantly elevated after starvation but were unchanged after HPLC. Minimal model insulin sensitivity was reduced after starvation (5.7 +/- 1.5 vs 14.5 +/- 4.8 and 16.5 +/- 6.8 L min(-1) mU(-1) P < .05). Plasma glucose, plasma FFAs, IMCLs, and insulin sensitivity are maintained when an HPLC diet is consumed, despite other forms of carbohydrate deprivation producing marked changes in these measures. We conclude that dietary carbohydrate restriction does not cause circulating FFA to become elevated. However, it remains possible that circulating carbohydrate status has an important influence on plasma FFA and therefore insulin sensitivity in healthy people. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据