期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 58, 期 10, 页码 1372-1378出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2009.05.001
关键词
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资金
- Japan Society for the Promotion of Science [17590564]
- Grants-in-Aid for Scientific Research [17590564] Funding Source: KAKEN
We studied whether electroacupuncture (EA) applied oil the abdomen improved glucose tolerance in the Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes mellitus. Male GK rats and nondiabetic Wistar rats were studied under pentobarbital anesthesia. Blood samples were drawn from the ventral tail artery during the fasting stage and after a glucose load (0.5 g/kg). Electroacupuncture (15 Hz, 10 mA) was performed for 90 minutes during both the fasting and intravenous glucose tolerance test (IVGTT) periods. A hyperinsulinemic euglycemic clamp was also carried out to assess glucose uptake during EA. A significant decrease in fasting blood glucose and ail increase in plasma insulin levels were observed during the fasting period in GK rats treated with EA. Blood glucose levels after glucose load were also significantly lower in GK rats treated with EA compared with controls. The homeostasis model assessment index during IVGTT indicated an improvement in insulin sensitivity in GK rats treated with EA, whereas glucose infusion rate during hyperinsulinemic clamp was increased significantly during EA. The present study demonstrated that EA improved hyperglycemia in the fasting stage with a marked increase in plasma insulin levels. Electroacupuncture also restored impaired glucose tolerance during ail IVGTT in GK rats by enhancing insulin sensitivity. (c) 2009 Elsevier Inc. All rights reserved.
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